A-67 Measuring Regional Cerebral Blood Flow with Single-Photon Emission Computed Tomography (SPECT) in Obsessive–Compulsive Disorder

Abstract Objective To identify regional cerebral blood flow (rCBF) differences between individuals with Obsessive–Compulsive Disorder (OCD) and healthy controls. Mehtods: Healthy controls (n = 81, Mage 41.9, 53.0% female, 42.0% Caucasian) persons diagnosed by psychiatric examination OCD 1020, 34.8, 33.6% 66.3% were selected from a deidentified adult clinical outpatient database. Those comorbid diagnoses included. Significant (alpha 0.001) found for age [t(1099) −4.4], gender [χ2(2) 25.7], race [χ2(12) 30.1] groups therefore controlled for. rCBF noted in the cerebellum [left:F(1,1096) 21.6; right:F(1,1096) 18.3], limbic system 12.2; 10.4], basal ganglia 18.6; 18.3]. Results Group means comparisons indicated higher perfusion group. Lower was This study among Previous research increased left before pharmacotherapy. In right cerebellum, participants early-onset OCD. Conclusion Overall, there is limited on because of its use as reference point. No regarding using SPECT; however, other neuroimaging amygdala reactivity to emotional face stimuli. lower hypoperfusion right; not significant. Updated SPECT are needed. Limitations included inclusion comorbidities DSM-IV-TR rather than DSM-5 diagnosis criteria.